Basic Information
| LncRNA/CircRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 |
| Ensemble | ENSG00000177640 |
| Refseq | NR_026939 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | HCC tissues, cell lines (HepG2, HuH7) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA CASC2, acting as an onco-suppressor, was involved in the pathogenesis and progression of HCC, and its possible mechanism was induced the growth inhibition on HCC through miR-24-3p/SOX7 axis. Our results revealed a possible regulatory mechanism in HCC pathogenesis and warranted that lncRNA CASC2 was an important regulator in HCC. |
| Pubmed ID | 29091305 |
| Year | 2017 |
| Title | LncRNA CASC2 inhibited the viability and induced the apoptosis of hepatocellular carcinoma cells through regulating miR-24-3p |
External Links
| Links for CASC2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |