Basic Information
| LncRNA/CircRNA Name | CASC21 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000253929 |
| Refseq | NR_117099 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qRT-PCR, RNA-seq, Western blotting assay |
| Sample | colon cancer cell lines (HT29, HCT116, SW480, SW620 and LOVO),colon cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Functionally, CASC21 promoted cell proliferation by regulating cell cycle and enhanced tumour metastasis by epithelial-mesenchymal transition (EMT) in colon cancer. Mechanism study indicated that CASC21 might be involved in activating WNT/?-catenin pathway in colon cancer. CASC21 knockdown suppresses cell proliferation and induces cell apoptosis in colon cancer. |
| Pubmed ID | 31965704 |
| Year | 2020 |
| Title | Integrative Analysis and Validation of Dysregulated Long Non-Coding RNAs in Colon Cancer |
External Links
| Links for CASC21 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |