Basic Information
| LncRNA/CircRNA Name | YIYA |
| Synonyms | LINC00538, PROX1UT, Yiya |
| Region | GRCh38_1:213924749-213926654 |
| Ensemble | ENSG00000281664 |
| Refseq | NR_046189 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, in vitro knockdown, RIP |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF7, BT474 and HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | YIYA is upregulated in breast cancer cells compared to normal mammary gland epithelial cells. Upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA is associated with the cytosolic cyclin-dependent kinase CDK6 and regulated CDK6-dependent phosphorylation of the fructose bisphosphatase PFK2 (PFKFB3) in a cell-cycle-independent manner. In breast cancer cells, these events promoted catalysis of glucose 6-phosphate to fructose-2,6-bisphosphate/fructose-1,6-bisphosphate. CRISPR/Cas9-mediated deletion of YIYA or CDK6 silencing impaired glycolysis and tumor growth in vivo In clinical specimens of breast cancer, YIYA was expressed in approximately 40% of cases where it correlated with CDK6 expression and unfavorable survival outcomes. High YIYA expression exhibited poor recurrence free survival. |
| Pubmed ID | 29967256 |
| Year | 2018 |
| Title | Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer |
External Links
| Links for YIYA | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |