Basic Information
| LncRNA/CircRNA Name | Z38 |
| Synonyms | CLDND1, Z38, C3orf4, GENX-3745 |
| Region | GRCh38_3:98497912-98523066 |
| Ensemble | ENSG00000080822 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | gastric cancer tissues and cell lines(KATO III, SGC-7901 and AGS) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of Z38 decreased the cell proliferative rate, as evidenced by colony formation assays and cell proliferation assays. In addition, Transwell assays and wound-healing assays demonstrated that depletion of Z38 significantly inhibited cell migration and invasion in AGS and MKN74 cells. Furthermore, a cell apoptosis assay and measurement of relative activities of related caspases revealed that depletion of Z38 increased cell apoptosis by promoting the activities of caspase-3 and caspase-9, but not that of caspase-8. Finally, western blot analysis further demonstrated the role of Z38 in the apoptosis of AGS and MKN74 cells. |
| Pubmed ID | 30333877 |
| Year | 2018 |
| Title | Long Noncoding RNA Z38 Promotes Cell Proliferation and Metastasis and Inhibits Cell Apoptosis in Human Gastric Cancer |
External Links
| Links for Z38 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |