Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 was upregulated in NSCLC tissues compared to adjacent non-tumor tissues. In addition, upregulated lncRNA ZEB1-AS1 expression was significantly associated with lymph node metastasis and TNM stage (P<0.05). Furthermore, patients with increased expression of lncRNA ZEB1-AS1 had poor OS (HR=3.202, 95% CI=2.018-5.078, P<0.001). Multivariate Cox proportional hazards model analysis demonstrated that high lncRNA ZEB1-AS1 expression was an independent poor prognostic factor for NSCLC patients. |
| Pubmed ID | 31949753 |
| Year | 2018 |
| Title | Increased Expression of lncRNA ZEB1-AS1 in Non-Small Cell Lung Cancer Is Associated With Poor Prognosis |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |