Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | zinc finger E-box-binding homeobox 1 antisense 1 |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | COAD tissues,primary COAD cell lines (SW480, HT29, LS174T, HCT116 and DLD-1) and normal human colon histiocytes (CCD-18Co) |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 expression was significantly up-regulated in COAD tissues, and high ZEB1-AS1 level was correlated with the poor prognosis of COAD patients.ZEB1-AS1 promotes PAK2 expression by sponging miR-455-3p, thus facilitating COAD cell growth and metastasis. |
| Pubmed ID | 31828845 |
| Year | 2020 |
| Title | Long Non-Coding RNA ZEB1-AS1 Promotes Colon Adenocarcinoma Malignant Progression via miR-455-3p/PAK2 Axis |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for colon adenocarcinoma | OMIM COSMIC |