Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , Western blot , RIP , in vitro knockdown etc. |
| Sample | BCa tissues and normal adjacent tissues?,human BCa cell lines(T24 and UM-UC-3) ,normal bladder epithelial SV-HUC-1 cell line |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 was upregulated in BCa cells compared with normal epithelial cells.Functionally, knockdown of ZEB1-AS1 suppressed BCa cell migration and invasion in vitro, and metastasis in vivo.ZEB1-AS1 bound to heterogenous nuclear ribonucleoprotein D0 (AUF1), thereby activating the translation of ZEB1 mRNA without affecting its mRNA level.In addition, ZEB1-AS1 was significantly upregulated in BCa tissues and muscle-invasive BCa cases.ZEB1-AS1 expression was associated with metastasis in patients with BCa. |
| Pubmed ID | 31115480 |
| Year | 2019 |
| Title | lncRNA ZEB1-AS1 Promotes Migration and Metastasis of Bladder Cancer Cells by Post-Transcriptional Activation of ZEB1 |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |