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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Western blot, in vitro knockdown, etc.
Sample	primary gastric carcinoma tissues, human gastric carcinoma cell lines (SGC-7901, BGC-823, and MKN45) and an immortalized normal gastric epithelial cell line GES-1
Expression Pattern	up-regulated
Function Description	ZEB2- AS1 expression was firstly detected in the gastric carcinoma tissue samples as well as in gastric cancer cells. We found ZEB2-AS1 expression was increased in gastric carcinoma samples, and it was correlated with tumor progression. Also, its expression was elevated in gastric cancer cells. Knockdown of ZEB2-AS1 reduced the proliferation, migration, invasion, and EMT, but increased the apoptosis of gastric carcinoma cells. Furthermore, ZEB2-AS1 downregulation remarkably suppressed the expression of Ki-67, PCNA, VEGF and MMP9, and the activation of Wnt/?-catenin signaling, whereas elevated the levels of cleaved caspase 3/8/9 and PARP in gastric cancer cells. And ZEB2 overexpression reversed the effects of ZEB2-AS1 downregulation on the proliferation, EMT and inactivation of Wnt/?-catenin signaling. Additionally, ZEB2-AS1 knockdown inhibited tumor growth, Ki-67 staining, and the expression of VEGF, MMP9, active ?-catenin, c-Myc, cyclinD1, and AXIN2 in mice.
Pubmed ID	30635820
Year	2019
Title	LncRNA ZEB2-AS1 contributes to the tumorigenesis of gastric cancer via activating the Wnt/?-catenin pathway.

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