Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | cell lines(MCF-10A, T47D, MCF-7, MDA-MB-435 and BT549) |
| Expression Pattern | up-regulated |
| Function Description | As a result, ZFAS1 expression was increased and miR-589 expression was decreased in BC cells. And, miR-589 was demonstrated to be a target of ZFAS1. ZFAS1 overexpression could inhibit the proliferation, colony formation, invasion and migration of BC cells while miR-589 overexpression could reverse the changes. In addition, ZFAS1 overexpression suppressed the expression of PI3K/AKT signal pathway by activating the PTEN expression while miR-589 overexpression could reverse the changes. |
| Pubmed ID | 32189153 |
| Year | 2020 |
| Title | LncRNA ZFAS1/miR-589 Regulates the PTEN/PI3K/AKT Signal Pathway in the Proliferation, Invasion and Migration of Breast Cancer Cells |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |