Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR, Western blot analysis, Dual luciferase reporter gene assay |
| Sample | tumor tissue,OS cells 143B, U2OS, Saos2, MG63 and human normal osteoblasts hFOB1.19 |
| Expression Pattern | up-regulated |
| Function Description | Overexpressed ZFAS1 and APEX1, and down-regulated miR-135a existed in OS tissues and cells. Silenced ZFAS1 or elevated miR-135a inhibited colony formation and proliferation, cycle progression, migration and invasion while promoted apoptosis of MG63 cells. Silenced ZFAS1 or elevated miR-135a suppressed tumor volume and weight of OS in vivo. LncRNA ZFAS1 promoted APEX1 expression by competitively binding with miR-135a. |
| Pubmed ID | 31827400 |
| Year | 2019 |
| Title | Silencing lncRNA ZFAS1 or Elevated microRNA-135a Represses Proliferation, Migration, Invasion and Resistance to Apoptosis of Osteosarcoma Cells |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |