Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | zinc finger antisense 1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute promyelocytic leukemia |
| ICD-0-3 | NA |
| Methods | RT-qPCR, RNAi, Western blot assay |
| Sample | peripheral blood samples,NB4 and NB4-all-trans retinoic acid-resistant (NB4-R-ATRA) cell lines |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was significantly overexpressed compared with the level in healthy controls.silencing of ZFAS1 by small interfering RNA significantly inhibited cell proliferation in APL cells. Moreover, downregulation of ZFAS1 increased cellular apoptosis, decreased expression of B-cell lymphoma-2 and of induced myeloid leukemia cell differentiation protein Mcl-1, increased the expression of apoptosis regulator BAX and promoted the release of cytochrome c and Diablo homolog mitochondrial into the cytoplasm. |
| Pubmed ID | 31807158 |
| Year | 2019 |
| Title | Long Non-Coding RNA Zinc Finger Antisense 1 Functions as an Oncogene in Acute Promyelocytic Leukemia Cells |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for acute promyelocytic leukemia | OMIM COSMIC |