Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | OS cell lines (U2OS, Saos-2, and MG-63) and normal human osteoblastic cell line (NHOst) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was up-regulated in OS cells and promoted the colony formation, migration, and invasion of OS cells via activating the MAPK signaling pathway.Furthermore, miR-646 was a target of ZFAS1 and there was a negative relationship between ZFAS1 and miR-646 expression.ZFAS1 in OS cells up-regulated the expression of NOB1 through sponging miR-646, finally facilitating the growth of the OS cells. |
| Pubmed ID | 31081072 |
| Year | 2019 |
| Title | Long Non-Coding RNA ZFAS1 Regulates NOB1 Expression Through Interacting With miR-646 and Promotes Tumorigenesis in Osteosarcoma |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |