Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | nasopharyngeal carcinoma cell lines (5-8F, CNE1, CNE2, C666), normal nasopharyngeal epithelium cell line (NP69), nasopharyngeal carcinoma tissues, normal nasopharyngeal tissues |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was significantly upregulated in NPC tissues and cell lines. Silencing ZFAS1 significantly inhibited cell proliferation and invasion, arrested cell cycle progression and promoted cell apoptosis, as well as reduced epithelial-mesenchymal transition. Moreover, 740Y-P could rescue the effects of ZFAS1 knockdown on proliferation, apoptosis and invasion in 5-8F cells.ZFAS1 might play an oncogenic role in NPC and facilitate cell proliferation and invasion via the PI3K/AKT signaling pathway in NPC cells. |
| Pubmed ID | 31403940 |
| Year | 2019 |
| Title | LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |