Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | EOC tissues, cell lines (OVCAR3, Caov3, OVCA429, SKOV3, A2780, and COV644) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was upregulated in epithelial ovarian cancer tissues, and was negatively correlated to the overall survival rate of patients.While depletion of ZFAS1 inhibited proliferation, migration, and development of chemoresistance, overexpression of ZFAS1 exhibited an even higher proliferation rate, migration activity, and chemoresistance in EOC cell lines. We further found miR-150-5p was a potential target of ZFAS1, which was downregulated in epithelial ovarian cancer tissue.MiR-150-5p subsequently inhibited expression of transcription factor Sp1, as evidence by luciferase assays. Inhibition of miR-150-5p rescued the suppressed proliferation and migration induced by depletion of ZFAS1 in epithelial ovarian cancer cells,at least in part. |
| Pubmed ID | 28099946 |
| Year | 2017 |
| Title | Long non-coding RNA ZFAS1 interacts with miR-150-5p to regulate Sp1 expression and ovarian cancer cell malignancy. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |