Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, Northern blot, ISH etc. |
| Sample | breast cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | The result shows ZFAS1 expression is decreased in ductal carcinoma relative to normal epithelial cells. We propose a functional role for Zfas1/ ZFAS1 in the regulation of alveolar development and epithelial cell differentiation in the mammary gland, which, together with its dysregulation in human breast cancer, suggests ZFAS1 as a putative tumor suppressor gene. |
| Pubmed ID | 21460236 |
| Year | 2011 |
| Title | SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |