Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | NA |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | hepatocellular carcinoma tissues, cell lines (HLE and Huh-7) |
| Expression Pattern | up-regulated |
| Function Description | CASC9 expression levels were elevated in patient-derived tumor samples compared to normal control tissue and had a significant association with overall survival of HCC patients. Further, CASC9 depletion caused an increase in apoptosis and a decrease of proliferation. In a xenograft chicken chorioallantoic membrane model, we measured decreased tumor size after knockdown of CASC9. |
| Pubmed ID | 29790588 |
| Year | 2018 |
| Title | The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |