Basic Information
| LncRNA/CircRNA Name | ZFAT-AS1 |
| Synonyms | ZFAT antisense RNA 1 |
| Region | GRCh38_8:134598071-134600689 |
| Ensemble | ENSG00000248492 |
| Refseq | NR_002438 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | Brain Tissues and Glioma Specimens,HEK293T and human glioma cell lines (U87 and U251) |
| Expression Pattern | down-regulated |
| Function Description | DGCR8 and CDX2 were highly expressed and ZFAT-AS1 was markedly downregulated in glioma tissues and cells. DGCR8 or CDX2 knockdown or ZFAT-AS1 overexpression suppressed glioma cell proliferation, migration, and invasion and facilitated apoptosis.ZFAT-AS1 could inhibit CDX2 transcription by mediating the methylation of histone H3 on lysine 27 (H3K27me3) modification induced by PRC2 in the CDX2 promoter region. |
| Pubmed ID | 31813799 |
| Year | 2020 |
| Title | DGCR8/ZFAT-AS1 Promotes CDX2 Transcription in a PRC2 Complex-Dependent Manner to Facilitate the Malignant Biological Behavior of Glioma Cells |
External Links
| Links for ZFAT-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |