Basic Information
| LncRNA/CircRNA Name | ZFPM2-AS |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | small cell lung cancer (SCLC) tissues and matched normal tissues,cell lines (16-HBE,DMS-53, H446, SHP-77, H69) |
| Expression Pattern | up-regulated |
| Function Description | ZFPM2-AS1 was significantly upregulated in SCLC tissues and cells. ZFPM2-AS1 deficiency attenuated SCLC cell proliferation, invasion and migration. In addition, ZFPM2-AS1 was transcriptionally activated by Yin Yang 1 (YY1) factor. Further, miR-3612 was confirmed as downstream miRNA of ZFPM2-AS1. |
| Pubmed ID | 32280300 |
| Year | 2020 |
| Title | YY1-induced lncRNA ZFPM2-AS1 facilitates cell proliferation and invasion in small cell lung cancer via upregulating of TRAF4 |
External Links
| Links for ZFPM2-AS | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |