Basic Information
| LncRNA/CircRNA Name | ZNF300P1 |
| Synonyms | ZNF300P1 |
| Region | GRCh38_5:150930645-150946289 |
| Ensemble | ENSG00000197083 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, MSH-PCR etc. |
| Sample | cell lines (SKOV3, OVCAR3, IGROV, OV90, COLO316, A2780 and CaOV3) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrate that ZNF300P1 is methylated in multiple ovarian cancer cell lines. Loss of ZNF300P1 results in decreased cell proliferation and colony formation. In addition, knockdown of the ZNF300P1 transcript results in aberrant and less persistent migration in wound healing assays due to a loss of cellular polarity. Using an ex vivo peritoneal adhesion assay, we also reveal a role for ZNF300P1 in the attachment of ovarian cancer cells to peritoneal membranes, indicating a potential function of ZNF300P1 expression in metastasis of ovarian cancer cells to sites within the peritoneal cavity. |
| Pubmed ID | 24393131 |
| Year | 2014 |
| Title | ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer. |
External Links
| Links for ZNF300P1 | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |