Basic Information
| LncRNA/CircRNA Name | ZNFX1-AS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot |
| Sample | CRC tissues and cell lines(SW620, SW480, HT-29, DLD-1, RKO, LOVO) |
| Expression Pattern | up-regulated |
| Function Description | We found that lncRNA ZNFX1-AS1 expression was significantly upregulated in CRC tissues and cell lines, and the expression of lncRNA ZNFX1-AS1 was associated with aggressive tumor phenotype and poor prognosis in CRC. |
| Pubmed ID | 30770796 |
| Year | 2019 |
| Title | Long non-coding RNA ZNFX1-AS1 promotes the tumor progression and metastasis of colorectal cancer by acting as a competing endogenous RNA of miR-144 toregulate EZH2 expression. |
External Links
| Links for ZNFX1-AS1 | GenBank HGNC NONCODE |
| Links for Colorectal cancer | OMIM COSMIC |