Basic Information
| LncRNA/CircRNA Name | circNFIC |
| Synonyms | circ_0002018 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blotting |
| Sample | breast cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | Further experiments revealed that overexpressing circNFIC suppressed breast cancer cell proliferation and migration to the lung. A mechanistic study showed that circNFIC acted as a sponge for miR-658 and competed for binding to miR-658 with UPK1A, leading to increased expression of UPK1A. |
| Pubmed ID | 32368305 |
| Year | 2020 |
| Title | circNFIC suppresses breast cancer progression by sponging miR-658 |
External Links
| Links for circNFIC | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |