Basic Information
| LncRNA/CircRNA Name | circAPLP2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, flow cytometry, western blotting |
| Sample | colorectal cancer tissue and cell line |
| Expression Pattern | up-regulated |
| Function Description | circAPLP2 expression was enhanced in CRC tissues and cells. circAPLP2 knockdown or miR-485-5p overexpression suppressed cell proliferation, migration, and invasion, whereas it promoted apoptosis in CRC cells, which was reversed by upregulating FOXK1. |
| Pubmed ID | 32343603 |
| Year | 2020 |
| Title | Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis |
External Links
| Links for circAPLP2 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |