Basic Information
| LncRNA/CircRNA Name | circSMC3 |
| Synonyms | circ_0000260 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blotting |
| Sample | gastric cancer tissues |
| Expression Pattern | differential expressed |
| Function Description | Patients with high circSMC3 expression levels had a poor overall survival via Kaplan-Meier survival analysis implied that gastric cancer. Functionally, loss of circSMC3 abolished the proliferation and motility of gastric cancer cells. Mechanically, circSMC3 decreased miR-4720-3p expression by acting as a miRNA sponge |
| Pubmed ID | 32314520 |
| Year | 2020 |
| Title | CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis |
External Links
| Links for circSMC3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |