Basic Information
| LncRNA/CircRNA Name | circ_0000527 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, RIP, western blotting |
| Sample | retinoblastoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | It was demonstrated that expression level of circ_0000527 in RB samples was significantly up-regulated compared to normal tissues, while miR-646 was markedly down-regulated. Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR-646 transfection had the opposite effects. |
| Pubmed ID | 32266733 |
| Year | 2020 |
| Title | Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis |
External Links
| Links for circ_0000527 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |