Basic Information
LncRNA/CircRNA Name | circCCDC66 |
Synonyms | |
Region | |
Ensemble | |
Refseq |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | gastric cancer |
ICD-0-3 | C16 |
Methods | qPCR |
Sample | gastric cancer tissues and cell lines |
Expression Pattern | up-regulated |
Function Description | CircCCDC66 expression was elevated in both GC tissues and cell lines compared to adjacent normal tissues and normal gastric epithelial cell line. The upregulation of circCCDC66 in GC tissues was related to tumor stage and lymphatic metastasis. CircCCDC66 knockdown significantly inhibited GC cell proliferation, migration and invasion and induced cell apoptosis in GC cells. |
Pubmed ID | 32226494 |
Year | 2020 |
Title | Circular RNA CCDC66 promotes gastric cancer progression by regulating c-Myc and TGF-? signaling pathways |
External Links
Links for circCCDC66 | GenBank HGNC NONCODE |
Links for gastric cancer | OMIM COSMIC |