Basic Information
| LncRNA/CircRNA Name | circNFIX |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | serum |
| Expression Pattern | up-regulated |
| Function Description | Our results indicated that exosomal CircNFIX was up-regulated in the serum of TMZ-resistant patients and predicted poor prognosis. Exosomal CircNFIX from TMZ-resistant cells conferred TMZ resistance to recipient sensitive cells through the enhancement of cell migration and invasion and the repression of cell apoptosis under TMZ exposure. CircNFIX directly interacted with miR-132 by binding to miR-132. |
| Pubmed ID | 32194140 |
| Year | 2020 |
| Title | Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma |
External Links
| Links for circNFIX | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |