Basic Information
| LncRNA/CircRNA Name | circAKT1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR |
| Sample | cervical cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | We confirmed the high expression of circ-AKT1 in CC samples and cell lines, as well as the circle structure of circ-AKT1. Functionally, gain- and loss-of-function experiments indicated that circ-AKT1 and AKT1 promoted CC cell proliferation and invasion. Moreover, circ-AKT1 and AKT1 were induced by transforming growth factor beta (TGF-?) and facilitated EMT (epithelial-mesenchymal transition) in CC. |
| Pubmed ID | 32193155 |
| Year | 2020 |
| Title | circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression |
External Links
| Links for circAKT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |