Basic Information
| LncRNA/CircRNA Name | circMRPS35 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, CCK-8 and cell invasion assays |
| Sample | gastric cancer tissues |
| Expression Pattern | differential expressed |
| Function Description | Here, a novel circRNA named circMRPS35, was screened out by RNA-seq in gastric cancer tissues, whose expression is related to clinicopathological characteristics and prognosis in gastric cancer patients. Thus, it dramatically activates the transcription of FOXO1/3a and triggers subsequent response of their downstream target genes expression, including p21, p27, Twist1 and E-cadherin, resulting in the inhibition of cell proliferation and invasion. |
| Pubmed ID | 32164722 |
| Year | 2020 |
| Title | CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification |
External Links
| Links for circMRPS35 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |