Basic Information
| LncRNA/CircRNA Name | circPVT1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Dual luciferase reporter experiment |
| Sample | osteosarcoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | circPVT1 and c-FLIP were highly expressed, while miR-205-5p was lowly expressed in OS tissues and cell lines. Knockdown of circPVT1 repressed cell proliferation, migration and invasion via inhibiting epithelial-mesenchymal transition (EMT) in OS. |
| Pubmed ID | 32110097 |
| Year | 2020 |
| Title | circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma |
External Links
| Links for circPVT1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |