Basic Information
| LncRNA/CircRNA Name | circIGF1R |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | lung cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | The expression level of circ-IGF1R was notably lower in lung cancer tissues and lung cancer cell lines than in the adjacent normal tissues and cells (P????.0001). In addition, the expression level of circ-IGF1R was associated with larger tumors (T2/T3/T4) and lymph node metastasis (N1/ N2/N3) (P????.05). The overexpression of circ-IGF1R significantly inhibited the invasion and migration of the lung cancer cells. |
| Pubmed ID | 32107851 |
| Year | 2020 |
| Title | Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer |
External Links
| Links for circIGF1R | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |