Basic Information
| LncRNA/CircRNA Name | circSMAD7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | circ-SMAD7 expression was significantly lower in GC tissues compared to that in adjacent ones. Cell migration and invasion of GC were inhibited via upregulation of circ-SMAD7. Moreover, the results of further experiments revealed that the EMT-related proteins were regulated via upregulation of circ-SMAD7 in GC. Furthermore, tumor metastasis of GC was inhibited via upregulation of circ-SMAD7 in nude mice. |
| Pubmed ID | 32096163 |
| Year | 2020 |
| Title | Upregulation of circular SMAD7 inhibits tumorigenesis of gastric cancer by reversing epithelial-to-mesenchymal transition |
External Links
| Links for circSMAD7 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |