Basic Information
| LncRNA/CircRNA Name | circPRMT5 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, western blotting, Dual luciferase reporter assay, and RNA immunoprecipitation (RIP) assay |
| Sample | liver cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Circ-PRMT5 was elevated in HCC tissues and cells than matched control groups. Furthermore, loss-of-functional experiments revealed that the silencing of circ-PRMT5 could repress proliferation, migration, glycolysis in vitro and tumor growth in vivo. |
| Pubmed ID | 32089501 |
| Year | 2020 |
| Title | Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis |
External Links
| Links for circPRMT5 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |