Basic Information
| LncRNA/CircRNA Name | circ_VCAN |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, cell counting kit-8, flow cytometry, Wound healing, and Transwell assays |
| Sample | glioma tissues |
| Expression Pattern | up-regulated |
| Function Description | Our results revealed that circ_VCAN was significantly upregulated in radioresistant glioma tissues compared with radiosensitive tissues. Both knockdown of circ_VCAN and treatment with miR-1183 mimics inhibited proliferation, migration, and invasion, and accelerated apoptosis of the irradiated U87 and U251 cells. |
| Pubmed ID | 32080097 |
| Year | 2020 |
| Title | The circ_VCAN with radioresistance contributes to the carcinogenesis of glioma by regulating microRNA-1183 |
External Links
| Links for circ_VCAN | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |