Basic Information
| LncRNA/CircRNA Name | circ_0000140 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR, western blotting, immunofluorescence, and immunohistochemistry |
| Sample | oral squamous cell carcinoma tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | It was down-regulated in OSCC tissues and cell lines, and correlated negatively with poor prognostic outcomes in OSCC patients. Gain-of-function experiments demonstrated that circ_0000140 enhancement suppressed cell proliferation, migration, and invasion, and facilitated cell apoptosis in vitro. In xenograft mouse models, overexpression of circ_0000140 was able to repress tumor growth and lung metastasis. |
| Pubmed ID | 32041942 |
| Year | 2020 |
| Title | circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway |
External Links
| Links for circ_0000140 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |