Basic Information
| LncRNA/CircRNA Name | circ_100290 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot |
| Sample | laryngeal squamous cell carcinoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that circRNA_100290 expression was significantly upregulated in LSCC tissues and cell lines compared with the normal controls. Expression of circRNA_100290 positively correlated with advanced TNM stage and lymph node metastasis in LSCC patients. In cell culture, upregulation of circRNA_100290 promoted LSCC cell proliferation, migration, and invasion, while it inhibited cell apoptosis |
| Pubmed ID | 32014687 |
| Year | 2020 |
| Title | Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p/RAP2C axis |
External Links
| Links for circ_100290 | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell carcinoma | OMIM COSMIC |