Basic Information
| LncRNA/CircRNA Name | circ_0005273 |
| Synonyms | circPTK2 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNA biotin-labeled pull down and mass spectrometry |
| Sample | colorectal cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | CircPTK2 was elevated in CRC tissues and positively associated with tumor growth and metastasis. CRC patients with increased circPTK2 expression were positively correlated with poorer survival rates. Furthermore, our studies showed that circPTK2 could promote EMT of CRC cells in vitro and in vivo by binding to vimentin protein on sites Ser38, Ser55 and Ser82. |
| Pubmed ID | 31973707 |
| Year | 2020 |
| Title | CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer |
External Links
| Links for circ_0005273 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |