Basic Information
| LncRNA/CircRNA Name | circ_002178 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | CD8+ T cells | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR |
| Sample | lung adenocarcinoma tissues, plasma and cell lines |
| Expression Pattern | up-regulated |
| Function Description | has-circRNA-002178 was further confirmed to be upregulated in the LUAD tissues, and LUAD cancer cells. Subsequently, we also found has-circRNA-002178 could enhance PDL1 expression via sponging miR-34 in cancer cells to induce T-cell exhaustion. More importantly, circRNA-002178 could be detected in exosomes of plasma from LUAD patients and could serve as biomarkers for LUAD early diagnosis. |
| Pubmed ID | 31949130 |
| Year | 2020 |
| Title | circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma |
External Links
| Links for circ_002178 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |