Basic Information
| LncRNA/CircRNA Name | circEGLN3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, cell counting kit-8, flow cytometric experiment, wound scratch and transwell experiments |
| Sample | renal cell carcinoma?tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | The results indicated that circ-EGLN3 was elevated in RCC tissues and cell lines and predicted unfavorable prognosis for the patients with RCC. Silenced circ-EGLN3 hindered cell proliferation, migration, and invasion but facilitated apoptosis of RCC cells. |
| Pubmed ID | 31904147 |
| Year | 2020 |
| Title | Circular RNA circ-EGLN3 promotes renal cell carcinoma proliferation and aggressiveness via miR-1299-mediated IRF7 activation |
External Links
| Links for circEGLN3 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |