Basic Information
| LncRNA/CircRNA Name | circ_51217 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR |
| Sample | prostate cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | Mechanism dissection revealed that R-2HG could increase circRNA-51217 expression to sponge miRNA-646, which might then lead to increase TGF?1 expression and thus induce TGF?1/p-Smad2/3 signaling to increase PCa cell invasion. |
| Pubmed ID | 31846689 |
| Year | 2020 |
| Title | Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGF?1/p-Smad2/3 signaling |
External Links
| Links for circ_51217 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |