Basic Information
| LncRNA/CircRNA Name | CAT104 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (MG63 and OS-732, hFOB1.19, HEK293) |
| Expression Pattern | up-regulated |
| Function Description | CAT104 was highly expressed in osteosarcoma MG-63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381 and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc finger E box binding homeobox 1 (ZEB1) was a direct target gene of miR-381, which was involved in the regulatory roles of miR381 in OS-732 cell proliferation, migration, invasion and apoptosis, as well as c-Jun Nterminal kinase (JNK) and Wnt/catenin pathways. Suppression of CAT104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration and invasion by regulating the expression of miR-381 and downstream ZEB1, as well as JNK and Wnt-catenin pathways. |
| Pubmed ID | 29523223 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA CAT104 inhibits the proliferation, migration and invasion of human osteosarcoma cells by regulating microRNA-381. |
External Links
| Links for CAT104 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |