Basic Information
| LncRNA/CircRNA Name | circKATNAL1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RNA pull down assay, RIP and Dual luciferase reporter gene assay |
| Sample | prostate cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | Circ_KATNAL1 and miR-145-3p promoted each other's expression, and down-regulated the expression of target gene WISP1. Both circ_KATNAL1 and miR-145-3p inhibited cell proliferation, invasion, migration and the expression of MMP-2 and MMP-9, promoted cell apoptosis and the activation of Caspase-3, Caspase-8, Caspase-9 and PARP, while WISP1 had the opposite effects, and the above functions of circ_KATNAL1 were performed through the miR-145-3p/WISP1 pathway. |
| Pubmed ID | 31800303 |
| Year | 2019 |
| Title | Circ_KATNAL1 regulates prostate cancer cell growth and invasion through miR-145-3p/WISP1 pathway |
External Links
| Links for circKATNAL1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |