Basic Information
| LncRNA/CircRNA Name | circSMAD7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, cell proliferation assay, cell cycle assay, transwell assay, and Matrigel assay |
| Sample | glioma tissues and cell lines |
| Expression Pattern | differential expressed |
| Function Description | Circ-SMAD7 expression was observed in glioma tissues when compared with adjacent samples. The expression of circ-SMAD7 was associated with patients' WHO stage and KPS score. Cell proliferation was inhibited and cell cycle was regulated after circ-SMAD7 was downregulated in glioma cells. Besides, cell migration and invasion were inhibited after circ-SMAD7 was downregulated in glioma cells. |
| Pubmed ID | 31799673 |
| Year | 2019 |
| Title | Circular RNA circ-SMAD7 promoted glioma cell proliferation and metastasis by upregulating PCNA |
External Links
| Links for circSMAD7 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |