Basic Information
| LncRNA/CircRNA Name | circ_0102049 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, CCK-8, flow cytometry, wound healing and transwell experiments |
| Sample | osteosarcoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Circ_0102049 was overexpressed in both OS specimens and cells. Moreover, the level of circ_0102049 in OS patients was markedly correlated with larger tumor size, pulmonary metastasis and poor prognosis. Circ_0102049 remarkably accelerated cell proliferation, migration and invasion but attenuated cell apoptosis in OS cells analyzed by gain/loss of function experiments. |
| Pubmed ID | 31727503 |
| Year | 2019 |
| Title | Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma |
External Links
| Links for circ_0102049 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |