Basic Information
| LncRNA/CircRNA Name | circASH2L |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Pancreatic Ductal Adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | qPCR, RIP, FISH, Dual luciferase assays, RNA pulldown and western blot |
| Sample | Pancreatic Ductal Adenocarcinoma tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | circ-ASH2L was highly expressed in pancreatic cells or tumor tissues and correlated with tumor malignancy. Further studies revealed that circ-ASH2L promoted tumor invasion, proliferation and angiogenesis by regulating miR-34a, thus regulate Notch 1 expression. |
| Pubmed ID | 31718694 |
| Year | 2019 |
| Title | Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma |
External Links
| Links for circASH2L | GenBank HGNC NONCODE |
| Links for Pancreatic Ductal Adenocarcinoma | OMIM COSMIC |