Basic Information
| LncRNA/CircRNA Name | circ_0074027 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, CCK-8 and Dual luciferase reporter assay |
| Sample | non-small cell lung cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | Overexpressed circ_0074027 was related to more advanced TNM stages, poorer differentiation grade, and worse overall survival. Upregulated circ_0074027 increased the proliferation of H1299 cells by inhibiting cell apoptosis. |
| Pubmed ID | 31680319 |
| Year | 2019 |
| Title | Circular RNA circ_0074027 Indicates a Poor Prognosis for NSCLC Patients and Modulates Cell Proliferation, Apoptosis, and Invasion via miR-185-3p Mediated BRD4/MADD Activation |
External Links
| Links for circ_0074027 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |