Basic Information
| LncRNA/CircRNA Name | circ_0004491 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qPCR and western blot |
| Sample | oral squamous cell carcinoma tissues and cell lines |
| Expression Pattern | down-regulated |
| Function Description | qRT-PCR analysis revealed that hsa_circ_0004491 was significantly downregulated in OSCC tissues compared with paired normal tissues , and this low expression was associated with lymph node metastasis. Hsa_circ_000449 silencing or overexpression significantly affected the invasion and migration abilities of OSCC cells. Western blotting analysis showed that EMT-related proteins expression was significantly changed after hsa_circ_000449 silencing or overexpression. |
| Pubmed ID | 31669576 |
| Year | 2019 |
| Title | Silencing Circular RNA hsa_circ_0004491 Promotes Metastasis of Oral Squamous Cell Carcinoma |
External Links
| Links for circ_0004491 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |