Basic Information
| LncRNA/CircRNA Name | circANKIB1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP assay, RNA pull down, and Dual luciferase reporter gene assay |
| Sample | osteosarcoma cell lines |
| Expression Pattern | differential expressed |
| Function Description | Circ_ANKIB1 promoted miR-19b expression, inhibited the expression of the downstream target gene SOCS3, and then activated the STAT3 pathway. Continuous detection of cell growth and invasion showed that the downregulation of circ_ANKIB1 or miR-19b significantly inhibited cell proliferation and invasion, but increased the apoptotic level. |
| Pubmed ID | 31667786 |
| Year | 2019 |
| Title | Circ_ANKIB1 Stabilizes the Regulation of miR-19b on SOCS3/STAT3 Pathway to Promote Osteosarcoma Cell Growth and Invasion |
External Links
| Links for circANKIB1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |