Basic Information
| LncRNA/CircRNA Name | circAF4 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, CCK-8, RIP, FISH |
| Sample | leukemia plasma and cell lines |
| Expression Pattern | differential expressed |
| Function Description | We showed that circAF4 plays an oncogenic role in MLL-AF4 leukemia and promotes leukemogenesis in vitro and in vivo. More importantly, knockdown of circAF4 increases the leukemic cell apoptosis rate in MLL-AF4 leukemia cells, while no effect was observed in leukemia cells that do not carry the MLL-AF4 translocation. |
| Pubmed ID | 31623653 |
| Year | 2019 |
| Title | circRNA circAF4 Functions as an Oncogene to Regulate MLL-AF4 Fusion Protein Expression and Inhibit MLL Leukemia Progression |
External Links
| Links for circAF4 | GenBank HGNC NONCODE |
| Links for leukemia | OMIM COSMIC |