Basic Information
| LncRNA/CircRNA Name | circPLEKHM3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR |
| Sample | ovarian cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | CircPLEKHM3 was identified as one of the most significantly down-regulated circRNAs in ovarian cancer tissues compared with normal tissues. circPLEKHM3 overexpression inhibited cell growth, migration and epithelial-mesenchymal transition, whereas its knockdown exerted an opposite role. |
| Pubmed ID | 31623606 |
| Year | 2019 |
| Title | CircPLEKHM3 Acts as a Tumor Suppressor Through Regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 Axis in Ovarian Cancer |
External Links
| Links for circPLEKHM3 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |