Basic Information
| LncRNA/CircRNA Name | circ_0021977 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR |
| Sample | colorectal cancer cell lines |
| Expression Pattern | differential expressed |
| Function Description | Low circ_0021977 expression in patients with CRC is associated with higher tug-lymph node metastasis (TNM) stage and poorer prognosis compared with patients with high circ_0021977 expression. The results showed that the circ_0021977/miR-10b-5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells. |
| Pubmed ID | 31595500 |
| Year | 2019 |
| Title | The circ_0021977/miR-10b-5p/P21 and P53 Regulatory Axis Suppresses Proliferation, Migration, and Invasion in Colorectal Cancer |
External Links
| Links for circ_0021977 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |